Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we ide...

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Detalles Bibliográficos
Autores principales: Sagar, Divya, Singh, Narendra P., Ginwala, Rashida, Huang, Xiaofang, Philip, Ramila, Nagarkatti, Mitzi, Nagarkatti, Prakash, Neumann, Konstantin, Ruland, Jürgen, Andrews, Allison M., Ramirez, Servio H., Khan, Zafar K., Jain, Pooja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457463/
https://www.ncbi.nlm.nih.gov/pubmed/28578388
http://dx.doi.org/10.1038/s41598-017-03027-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457463/
https://www.ncbi.nlm.nih.gov/pubmed/28578388
http://dx.doi.org/10.1038/s41598-017-03027-x

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