Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study

INTRODUCTION: To evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- and age combined clusters. In addition, we used the age-adjusted blood pressure thresholds to demonstrate the effect on the prevalence of MetS and elevated blood pr...

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Autores principales: Slagter, Sandra N, van Waateringe, Robert P, van Beek, André P, van der Klauw, Melanie M, Wolffenbuttel, Bruce H R, van Vliet-Ostaptchouk, Jana V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457493/
https://www.ncbi.nlm.nih.gov/pubmed/28420718
http://dx.doi.org/10.1530/EC-17-0011
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author Slagter, Sandra N
van Waateringe, Robert P
van Beek, André P
van der Klauw, Melanie M
Wolffenbuttel, Bruce H R
van Vliet-Ostaptchouk, Jana V
author_facet Slagter, Sandra N
van Waateringe, Robert P
van Beek, André P
van der Klauw, Melanie M
Wolffenbuttel, Bruce H R
van Vliet-Ostaptchouk, Jana V
author_sort Slagter, Sandra N
collection PubMed
description INTRODUCTION: To evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- and age combined clusters. In addition, we used the age-adjusted blood pressure thresholds to demonstrate the effect on the prevalence of MetS and elevated blood pressure. SUBJECTS AND METHODS: Cross-sectional data from 74,531 Western European participants, aged 18–79 years, were used from the Dutch Lifelines Cohort Study. MetS was defined according to the revised NCEP-ATPIII. Age-adjusted blood pressure thresholds were defined as recommended by the eight reports of the Joint National Committee (≥140/90 mmHg for those aged <60 years, and ≥150/90 mmHg for those aged ≥60 years). RESULTS: 19.2% men and 12.1% women had MetS. MetS prevalence increased with BMI and age. Independent of BMI, abdominal obesity dominated MetS prevalence especially in women, while elevated blood pressure was already highly prevalent among young men. Applying age-adjusted blood pressure thresholds resulted in a 0.2–11.9% prevalence drop in MetS and 6.0–36.3% prevalence drop in elevated blood pressure, within the combined sex, BMI and age clusters. CONCLUSIONS: We observed a gender disparity with age and BMI for the prevalence of MetS and, especially, abdominal obesity and elevated blood pressure. The strict threshold level for elevated blood pressure in the revised NCEP-ATPIII, results in an overestimation of MetS prevalence.
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spelling pubmed-54574932017-06-07 Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study Slagter, Sandra N van Waateringe, Robert P van Beek, André P van der Klauw, Melanie M Wolffenbuttel, Bruce H R van Vliet-Ostaptchouk, Jana V Endocr Connect Research INTRODUCTION: To evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- and age combined clusters. In addition, we used the age-adjusted blood pressure thresholds to demonstrate the effect on the prevalence of MetS and elevated blood pressure. SUBJECTS AND METHODS: Cross-sectional data from 74,531 Western European participants, aged 18–79 years, were used from the Dutch Lifelines Cohort Study. MetS was defined according to the revised NCEP-ATPIII. Age-adjusted blood pressure thresholds were defined as recommended by the eight reports of the Joint National Committee (≥140/90 mmHg for those aged <60 years, and ≥150/90 mmHg for those aged ≥60 years). RESULTS: 19.2% men and 12.1% women had MetS. MetS prevalence increased with BMI and age. Independent of BMI, abdominal obesity dominated MetS prevalence especially in women, while elevated blood pressure was already highly prevalent among young men. Applying age-adjusted blood pressure thresholds resulted in a 0.2–11.9% prevalence drop in MetS and 6.0–36.3% prevalence drop in elevated blood pressure, within the combined sex, BMI and age clusters. CONCLUSIONS: We observed a gender disparity with age and BMI for the prevalence of MetS and, especially, abdominal obesity and elevated blood pressure. The strict threshold level for elevated blood pressure in the revised NCEP-ATPIII, results in an overestimation of MetS prevalence. Bioscientifica Ltd 2017-04-18 /pmc/articles/PMC5457493/ /pubmed/28420718 http://dx.doi.org/10.1530/EC-17-0011 Text en © 2017 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Slagter, Sandra N
van Waateringe, Robert P
van Beek, André P
van der Klauw, Melanie M
Wolffenbuttel, Bruce H R
van Vliet-Ostaptchouk, Jana V
Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
title Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
title_full Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
title_fullStr Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
title_full_unstemmed Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
title_short Sex, BMI and age differences in metabolic syndrome: the Dutch Lifelines Cohort Study
title_sort sex, bmi and age differences in metabolic syndrome: the dutch lifelines cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457493/
https://www.ncbi.nlm.nih.gov/pubmed/28420718
http://dx.doi.org/10.1530/EC-17-0011
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