Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature viral particles. Anti-FLE antibodies are broadly cross-reactive but poorly...

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Detalles Bibliográficos
Autores principales: Rouvinski, Alexander, Dejnirattisai, Wanwisa, Guardado-Calvo, Pablo, Vaney, Marie-Christine, Sharma, Arvind, Duquerroy, Stéphane, Supasa, Piyada, Wongwiwat, Wiyada, Haouz, Ahmed, Barba-Spaeth, Giovanna, Mongkolsapaya, Juthathip, Rey, Félix A., Screaton, Gavin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457521/
https://www.ncbi.nlm.nih.gov/pubmed/28534525
http://dx.doi.org/10.1038/ncomms15411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457521/
https://www.ncbi.nlm.nih.gov/pubmed/28534525
http://dx.doi.org/10.1038/ncomms15411

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