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Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads

BACKGROUND: Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amino acid polypeptide, which attaches covalently to target proteins through com...

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Detalles Bibliográficos
Autores principales: Jain, Jagrati, Jain, Surendra K., Walker, Larry A., Tekwani, Babu L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457628/
https://www.ncbi.nlm.nih.gov/pubmed/28577368
http://dx.doi.org/10.1186/s40360-017-0147-4