Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition

Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent role in normal physiology and disease. PRMT4 or coactivator-associated arginine methyltransferase 1 (CARM1) is a propitious target for cancer therapy; however,...

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Detalles Bibliográficos
Autores principales: Shishkova, Evgenia, Zeng, Hao, Liu, Fabao, Kwiecien, Nicholas W., Hebert, Alexander S., Coon, Joshua J., Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458078/
https://www.ncbi.nlm.nih.gov/pubmed/28537268
http://dx.doi.org/10.1038/ncomms15571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458078/
https://www.ncbi.nlm.nih.gov/pubmed/28537268
http://dx.doi.org/10.1038/ncomms15571

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