Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq

Detection of de novo, low-frequency mutations is essential for characterizing cancer genomes and heterogeneous cell populations. However, the screening capacity of current ultrasensitive NGS methods is inadequate owing to either low-efficiency read utilization or severe amplification bias. Here, we...

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Detalles Bibliográficos
Autores principales: Wang, Kaile, Lai, Shujuan, Yang, Xiaoxu, Zhu, Tianqi, Lu, Xuemei, Wu, Chung-I, Ruan, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458117/
https://www.ncbi.nlm.nih.gov/pubmed/28530222
http://dx.doi.org/10.1038/ncomms15335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458117/
https://www.ncbi.nlm.nih.gov/pubmed/28530222
http://dx.doi.org/10.1038/ncomms15335

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