Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4/CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4/heparin complexes, causing the prothrombotic adverse drug...

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Detalles Bibliográficos
Autores principales: Nguyen, Thi-Huong, Medvedev, Nikolay, Delcea, Mihaela, Greinacher, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458132/
https://www.ncbi.nlm.nih.gov/pubmed/28530237
http://dx.doi.org/10.1038/ncomms14945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458132/
https://www.ncbi.nlm.nih.gov/pubmed/28530237
http://dx.doi.org/10.1038/ncomms14945

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