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Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8(+) T cells by preventing terminal effector differentiation

Long-surviving memory CD8(+) T cells generated by stimulation with appropriate tumor-associated antigens are the most aggressive and persistent tumoricidal effectors. In this event of memory CD8(+) T cell development, the signal transducer and activator of transcription (STAT) proteins function as t...

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Detalles Bibliográficos
Autores principales: Muraoka, Daisuke, Seo, Naohiro, Hayashi, Tae, Hyuga-Amaike, Chisaki, Okamori, Kana, Tawara, Isao, Harada, Naozumi, Shiku, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458166/
https://www.ncbi.nlm.nih.gov/pubmed/28430604
http://dx.doi.org/10.18632/oncotarget.15403