Oxidative DNA double strand breaks and autophagy in the antitumor effect of sterically hindered platinum(II) complexes in NSCLCs

A series of novel platinum(II) complexes with (1R,2R)-N(1),N(2)-diisobutyl-1,2-diaminocyclohexane as a carrier ligand, while N(1),N(2)-diisobutyl moiety serving as steric hindrance were designed, synthesized and characterized. The in vitro biological assays demonstrated that complex 3 had increased...

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Detalles Bibliográficos
Autores principales: Chen, Feihong, Wang, Xinyi, Jin, Xiufeng, Zhao, Jian, Gou, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458179/
https://www.ncbi.nlm.nih.gov/pubmed/28427237
http://dx.doi.org/10.18632/oncotarget.15944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458179/
https://www.ncbi.nlm.nih.gov/pubmed/28427237
http://dx.doi.org/10.18632/oncotarget.15944

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