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Oxidative DNA double strand breaks and autophagy in the antitumor effect of sterically hindered platinum(II) complexes in NSCLCs
A series of novel platinum(II) complexes with (1R,2R)-N(1),N(2)-diisobutyl-1,2-diaminocyclohexane as a carrier ligand, while N(1),N(2)-diisobutyl moiety serving as steric hindrance were designed, synthesized and characterized. The in vitro biological assays demonstrated that complex 3 had increased...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458179/ https://www.ncbi.nlm.nih.gov/pubmed/28427237 http://dx.doi.org/10.18632/oncotarget.15944 |