Low dose of 2-deoxy-D-glucose kills acute lymphoblastic leukemia cells and reverses glucocorticoid resistance via N-linked glycosylation inhibition under normoxia

Recent studies showed that 2-deoxy-D-glucose (2-DG), a glucose analog with dual activity of inhibiting glycolysis and N-linked glycosylation, can be selectively taken up by cancer cells and be used as a potential chemo- and radio-sensitizer. Meanwhile, 2-DG can kill cancer cells under normoxia. Howe...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Ling, Yi, Zhihui, Zhang, Yanle, Ma, Zhigui, Zhu, Yiping, Gao, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458182/
https://www.ncbi.nlm.nih.gov/pubmed/28415682
http://dx.doi.org/10.18632/oncotarget.16046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458182/
https://www.ncbi.nlm.nih.gov/pubmed/28415682
http://dx.doi.org/10.18632/oncotarget.16046

Ejemplares similares