Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

Interactions between the polo-like kinase 1 (PLK1) inhibitor volasertib and the histone deacetylase inhibitor (HDACI) belinostat were examined in diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells in vitro and in vivo. Exposure of DLBCL cells to very low concentrations of vol...

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Detalles Bibliográficos
Autores principales: Nguyen, Tri, Parker, Rebecca, Hawkins, Elisa, Holkova, Beata, Yazbeck, Victor, Kolluri, Akhil, Kmieciak, Maciej, Rahmani, Mohamed, Grant, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458223/
https://www.ncbi.nlm.nih.gov/pubmed/28416758
http://dx.doi.org/10.18632/oncotarget.15649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458223/
https://www.ncbi.nlm.nih.gov/pubmed/28416758
http://dx.doi.org/10.18632/oncotarget.15649

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