The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells

PURPOSE OF THE STUDY: Reduced levels of the tumor suppressor protein CCDC6 sensitize cancer cells to the treatment with PARP-inhibitors. The turnover of CCDC6 protein is regulated by the de-ubiquitinase USP7, which also controls the androgen receptor (AR) stability. Here, we correlated the expressio...

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Detalles Bibliográficos
Autores principales: Morra, Francesco, Merolla, Francesco, Napolitano, Virginia, Ilardi, Gennaro, Miro, Caterina, Paladino, Simona, Staibano, Stefania, Cerrato, Aniello, Celetti, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458250/
https://www.ncbi.nlm.nih.gov/pubmed/28415632
http://dx.doi.org/10.18632/oncotarget.16463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458250/
https://www.ncbi.nlm.nih.gov/pubmed/28415632
http://dx.doi.org/10.18632/oncotarget.16463

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