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The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells

PURPOSE OF THE STUDY: Reduced levels of the tumor suppressor protein CCDC6 sensitize cancer cells to the treatment with PARP-inhibitors. The turnover of CCDC6 protein is regulated by the de-ubiquitinase USP7, which also controls the androgen receptor (AR) stability. Here, we correlated the expressio...

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Detalles Bibliográficos
Autores principales:	Morra, Francesco, Merolla, Francesco, Napolitano, Virginia, Ilardi, Gennaro, Miro, Caterina, Paladino, Simona, Staibano, Stefania, Cerrato, Aniello, Celetti, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458250/ https://www.ncbi.nlm.nih.gov/pubmed/28415632 http://dx.doi.org/10.18632/oncotarget.16463

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