Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

Activated microglia can phagocytose dying, stressed, or excess neurons and synapses via the phagocytic receptor Mer tyrosine kinase (MerTK). Galectin-3 (Gal-3) can cross-link surface glycoproteins by binding galactose residues that are normally hidden below terminal sialic acid residues. Gal-3 was r...

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Detalles Bibliográficos
Autores principales: Nomura, Koji, Vilalta, Anna, Allendorf, David H., Hornik, Tamara C., Brown, Guy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2017
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458330/
https://www.ncbi.nlm.nih.gov/pubmed/28500071
http://dx.doi.org/10.4049/jimmunol.1502532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458330/
https://www.ncbi.nlm.nih.gov/pubmed/28500071
http://dx.doi.org/10.4049/jimmunol.1502532

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