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Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats

BACKGROUND: There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with enhanced expression of phosphorylated extracellular signal-regulated kinase 1/2 (...

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Detalles Bibliográficos
Autores principales: Borges, Gisela, Miguelez, Cristina, Neto, Fani, Mico, Juan Antonio, Ugedo, Luisa, Berrocoso, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458337/
https://www.ncbi.nlm.nih.gov/pubmed/28158734
http://dx.doi.org/10.1093/ijnp/pyx005