Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome

Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is characterized by craniofacial, growth, cognitive and cardiac defects. NS patients with kinase-activating RAF1 alleles typically develop pathological left ventricular hypertrophy (LVH), which is reproduced in Raf1(L613V/+) k...

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Detalles Bibliográficos
Autores principales: Yin, Jiani C., Platt, Mathew J., Tian, Xixi, Wu, Xue, Backx, Peter H., Simpson, Jeremy A., Araki, Toshiyuki, Neel, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458545/
https://www.ncbi.nlm.nih.gov/pubmed/28548091
http://dx.doi.org/10.1038/ncomms15518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458545/
https://www.ncbi.nlm.nih.gov/pubmed/28548091
http://dx.doi.org/10.1038/ncomms15518

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