Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Next-generation association studies can be empowered by sequence-based imputation and by studying founder populations. Here we report ∼9.5 million variants from whole-genome sequencing (WGS) of a Cretan-isolated population, and show enrichment of rare and low-frequency variants with predicted functi...

Descripción completa

Detalles Bibliográficos
Autores principales: Southam, Lorraine, Gilly, Arthur, Süveges, Dániel, Farmaki, Aliki-Eleni, Schwartzentruber, Jeremy, Tachmazidou, Ioanna, Matchan, Angela, Rayner, Nigel W., Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458552/
https://www.ncbi.nlm.nih.gov/pubmed/28548082
http://dx.doi.org/10.1038/ncomms15606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458552/
https://www.ncbi.nlm.nih.gov/pubmed/28548082
http://dx.doi.org/10.1038/ncomms15606

Ejemplares similares