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HSV-1 ICP27 induces apoptosis by promoting Bax translocation to mitochondria through interacting with 14-3-3θ

The subcellular localization of Bax plays a crucial role during apoptosis. In response to apoptotic stimuli, Bax translocates from the cytoplasm to the mitochondria, where it promotes the release of cytochrome c to the cytoplasm. In cells infected with HSV-1, apoptosis is triggered or blocked by div...

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Detalles Bibliográficos
Autores principales: Kim, Ji Ae, Kim, Jin Chul, Min, Jung Sun, Kang, Inho, Oh, Jeongho, Ahn, Jeong Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458675/
https://www.ncbi.nlm.nih.gov/pubmed/28256197
http://dx.doi.org/10.5483/BMBRep.2017.50.5.023