The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation

The Wnt/β-catenin signaling pathway plays essential roles in embryonic development and adult tissue homeostasis. Axin is a concentration-limiting factor responsible for the formation of the β-catenin destruction complex. Wnt signaling itself promotes the degradation of Axin. However, the underlying...

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Detalles Bibliográficos
Autores principales: Ji, Lei, Jiang, Bo, Jiang, Xiaomo, Charlat, Olga, Chen, Amy, Mickanin, Craig, Bauer, Andreas, Xu, Wenqing, Yan, Xiaoxue, Cong, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458757/
https://www.ncbi.nlm.nih.gov/pubmed/28546513
http://dx.doi.org/10.1101/gad.300053.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458757/
https://www.ncbi.nlm.nih.gov/pubmed/28546513
http://dx.doi.org/10.1101/gad.300053.117

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