Cargando…

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation

The Wnt/β-catenin signaling pathway plays essential roles in embryonic development and adult tissue homeostasis. Axin is a concentration-limiting factor responsible for the formation of the β-catenin destruction complex. Wnt signaling itself promotes the degradation of Axin. However, the underlying...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Lei, Jiang, Bo, Jiang, Xiaomo, Charlat, Olga, Chen, Amy, Mickanin, Craig, Bauer, Andreas, Xu, Wenqing, Yan, Xiaoxue, Cong, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458757/ https://www.ncbi.nlm.nih.gov/pubmed/28546513 http://dx.doi.org/10.1101/gad.300053.117

Ejemplares similares

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
por: Ji, Lei, et al.
Publicado: (2019)

Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway
por: Chen, Lianqi, et al.
Publicado: (2023)

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling
por: Callow, Marinella G., et al.
Publicado: (2011)

TRIM37 promotes gallbladder cancer proliferation by activating the Wnt/β-catenin pathway via ubiquitination of Axin1
por: Xu, Ming, et al.
Publicado: (2023)

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex
por: Schaefer, Kristina N., et al.
Publicado: (2020)

The E3 Ubiquitin Ligase TRIM11 Facilitates Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway via Destabilizing Axin1 Protein
por: Zhou, Ling, et al.
Publicado: (2022)

Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity
por: Gopalsamy, Anupriya, et al.
Publicado: (2014)

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2
por: Scortegagna, Marzia, et al.
Publicado: (2014)

Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa
por: Pepper, Ian J., et al.
Publicado: (2017)

SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression
por: Schmitz, M. Lienhard, et al.
Publicado: (2022)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

Siah Ubiquitin Ligases Modulate Nodal Signaling during Zebrafish Embryonic Development
por: Kang, Nami, et al.
Publicado: (2014)

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer
por: Chen, Anna, et al.
Publicado: (2014)

The Ubiquitin Ligase Siah2 Regulates Obesity-induced Adipose Tissue Inflammation
por: Kilroy, Gail, et al.
Publicado: (2015)

The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance
por: Burke, Susan J., et al.
Publicado: (2020)

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway
por: Wang, Yuting, et al.
Publicado: (2022)

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
por: Tacchelly-Benites, Ofelia, et al.
Publicado: (2018)

Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity
por: Gao, Rui, et al.
Publicado: (2016)

An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
por: Bernkopf, Dominic B., et al.
Publicado: (2019)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

Two high-resolution structures of the human E3 ubiquitin ligase Siah1
por: Rimsa, Vadim, et al.
Publicado: (2013)

“The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism”
por: Mekbib, Tsedey, et al.
Publicado: (2022)

E3 Ubiquitin Ligase Siah-1 is Down-regulated and Fails to Target Natural HBx Truncates for Degradation in Hepatocellular Carcinoma
por: Zhao, Jing, et al.
Publicado: (2016)

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection
por: Murphy Schafer, Ashleigh R., et al.
Publicado: (2020)

Wnt/Axin1/β-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries
por: Carl, Matthias, et al.
Publicado: (2007)

Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling
por: Wang, Zhenghan, et al.
Publicado: (2016)

SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status
por: Adam, M Gordian, et al.
Publicado: (2015)

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling
por: Berndt, Jason D., et al.
Publicado: (2011)

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
por: Peng, Yin, et al.
Publicado: (2021)

Allosteric Activation of the RNF146 Ubiquitin Ligase by a Poly(ADP-ribosyl)ation Signal
por: DaRosa, Paul A., et al.
Publicado: (2014)

MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease
por: Zhao, W., et al.
Publicado: (2019)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
por: Chen, Hsin-Yi, et al.
Publicado: (2019)

Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH
por: Christian, Perry A, et al.
Publicado: (2011)

The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer
por: Moreno, Paula, et al.
Publicado: (2015)

New insights into the regulation of Axin function in canonical Wnt signaling pathway
por: Song, Xiaomin, et al.
Publicado: (2014)

WNT/β-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma
por: Zhu, Liang, et al.
Publicado: (2020)

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin
por: Gillis, William Q., et al.
Publicado: (2016)

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
por: Topol, Lilia, et al.
Publicado: (2003)

C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling
por: Jiang, Jun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_64f75k9lb5sso8pmsoukhsukel