Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation

Cardiac fibroblasts (CFs) phenotypic conversion to myofibroblasts (MFs) represents a crucial event in cardiac fibrosis that leads to impaired cardiac function. However, regulation of this phenotypic transformation remains unclear. Here, we showed that sirtuin-7 (Sirt7) plays an important role in the...

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Detalles Bibliográficos
Autores principales: Wang, Haichen, Liu, Shengwu, Liu, Shengqiang, Wei, Wei, Zhou, Xiaolong, Lin, Fang, Wang, Juanjuan, Chen, Jinye, Zhang, Guodong, Pang, Yongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459426/
https://www.ncbi.nlm.nih.gov/pubmed/28582407
http://dx.doi.org/10.1371/journal.pone.0178530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459426/
https://www.ncbi.nlm.nih.gov/pubmed/28582407
http://dx.doi.org/10.1371/journal.pone.0178530

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