In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy

Noonan Syndrome with Multiple Lentigines (NSML, formerly LEOPARD syndrome) is an autosomal dominant "RASopathy" disorder manifesting in congenital heart disease. Most cases of NSML are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), non-receptor ty...

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Detalles Bibliográficos
Autores principales: Wang, Jianxun, Chandrasekhar, Vasanth, Abbadessa, Giovanni, Yu, Yi, Schwartz, Brian, Kontaridis, Maria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459472/
https://www.ncbi.nlm.nih.gov/pubmed/28582432
http://dx.doi.org/10.1371/journal.pone.0178905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459472/
https://www.ncbi.nlm.nih.gov/pubmed/28582432
http://dx.doi.org/10.1371/journal.pone.0178905

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