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Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations
Understanding the cellular-molecular substrates of heart disease is key to the development of cardiac specific therapies and to the prevention of off-target effects by non-cardiac targeted drugs. One of the primary targets for therapeutic intervention has been the human ether a go-go (hERG) K(+) cha...
Autores principales: | Ocorr, Karen, Zambon, Alexander, Nudell, Yoav, Pineda, Santiago, Diop, Soda, Tang, Min, Akasaka, Takeshi, Taylor, Erika |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459509/ https://www.ncbi.nlm.nih.gov/pubmed/28542428 http://dx.doi.org/10.1371/journal.pgen.1006786 |
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