Na(+) influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

T cell effector functions require sustained calcium influx. However, the signaling and phenotypic consequences of non-specific sodium permeation via calcium channels remain unknown. α-SNAP is a crucial component of Orai1 channels, and its depletion disrupts the functional assembly of Orai1 multimers...

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Detalles Bibliográficos
Autores principales: Miao, Yong, Bhushan, Jaya, Dani, Adish, Vig, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459575/
https://www.ncbi.nlm.nih.gov/pubmed/28492364
http://dx.doi.org/10.7554/eLife.25155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459575/
https://www.ncbi.nlm.nih.gov/pubmed/28492364
http://dx.doi.org/10.7554/eLife.25155

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