Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells

UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) plays a crucial role in DNA methylation, chromatin remodeling and gene expression and is aberrantly upregulated in various types of human cancers. However, the precise role of UHRF1 in cancer remains controversial. In this study, we observed...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Hyun, Shim, Jae-Woong, Eum, Da-Young, Kim, Sung Dae, Choi, Si Ho, Yang, Kwangmo, Heo, Kyu, Park, Moon-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459852/
https://www.ncbi.nlm.nih.gov/pubmed/28584306
http://dx.doi.org/10.1038/s41598-017-02935-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459852/
https://www.ncbi.nlm.nih.gov/pubmed/28584306
http://dx.doi.org/10.1038/s41598-017-02935-2

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