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Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
UHRF1 (ubiquitin-like, with PHD and RING finger domains 1) plays a crucial role in DNA methylation, chromatin remodeling and gene expression and is aberrantly upregulated in various types of human cancers. However, the precise role of UHRF1 in cancer remains controversial. In this study, we observed...
Autores principales: | Kim, Ji-Hyun, Shim, Jae-Woong, Eum, Da-Young, Kim, Sung Dae, Choi, Si Ho, Yang, Kwangmo, Heo, Kyu, Park, Moon-Taek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459852/ https://www.ncbi.nlm.nih.gov/pubmed/28584306 http://dx.doi.org/10.1038/s41598-017-02935-2 |
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