Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly conserved asparagine 297 (N)-linked biantenna...

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Detalles Bibliográficos
Autores principales: Peschke, Benjamin, Keller, Christian W., Weber, Patrick, Quast, Isaak, Lünemann, Jan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459932/
https://www.ncbi.nlm.nih.gov/pubmed/28634480
http://dx.doi.org/10.3389/fimmu.2017.00646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459932/
https://www.ncbi.nlm.nih.gov/pubmed/28634480
http://dx.doi.org/10.3389/fimmu.2017.00646

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