Engineered clearing agents for the selective depletion of antigen-specific antibodies

Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour t...

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Detalles Bibliográficos
Autores principales: Devanaboyina, Siva Charan, Khare, Priyanka, Challa, Dilip K., Ober, Raimund J., Ward, E. Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460014/
https://www.ncbi.nlm.nih.gov/pubmed/28561044
http://dx.doi.org/10.1038/ncomms15314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460014/
https://www.ncbi.nlm.nih.gov/pubmed/28561044
http://dx.doi.org/10.1038/ncomms15314

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