Engineered clearing agents for the selective depletion of antigen-specific antibodies

Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour t...

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Autores principales: Devanaboyina, Siva Charan, Khare, Priyanka, Challa, Dilip K., Ober, Raimund J., Ward, E. Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460014/
https://www.ncbi.nlm.nih.gov/pubmed/28561044
http://dx.doi.org/10.1038/ncomms15314
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author Devanaboyina, Siva Charan
Khare, Priyanka
Challa, Dilip K.
Ober, Raimund J.
Ward, E. Sally
author_facet Devanaboyina, Siva Charan
Khare, Priyanka
Challa, Dilip K.
Ober, Raimund J.
Ward, E. Sally
author_sort Devanaboyina, Siva Charan
collection PubMed
description Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.
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spelling pubmed-54600142017-06-12 Engineered clearing agents for the selective depletion of antigen-specific antibodies Devanaboyina, Siva Charan Khare, Priyanka Challa, Dilip K. Ober, Raimund J. Ward, E. Sally Nat Commun Article Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging. Nature Publishing Group 2017-05-31 /pmc/articles/PMC5460014/ /pubmed/28561044 http://dx.doi.org/10.1038/ncomms15314 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Devanaboyina, Siva Charan
Khare, Priyanka
Challa, Dilip K.
Ober, Raimund J.
Ward, E. Sally
Engineered clearing agents for the selective depletion of antigen-specific antibodies
title Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_full Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_fullStr Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_full_unstemmed Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_short Engineered clearing agents for the selective depletion of antigen-specific antibodies
title_sort engineered clearing agents for the selective depletion of antigen-specific antibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460014/
https://www.ncbi.nlm.nih.gov/pubmed/28561044
http://dx.doi.org/10.1038/ncomms15314
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