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HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
Immune responses primed by endogenous heat shock proteins, specifically gp96, can be varied, and mechanisms controlling these responses have not been defined. Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas high-dose immunization primes responses characteri...
Autores principales: | Kinner-Bibeau, Lauren B., Sedlacek, Abigail L., Messmer, Michelle N., Watkins, Simon C., Binder, Robert J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460028/ https://www.ncbi.nlm.nih.gov/pubmed/28561043 http://dx.doi.org/10.1038/ncomms15648 |
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