IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

NOTCH1 signalling contributes to defective remyelination by impairing differentiation of oligodendrocyte progenitor cells (OPCs). Here we report that IL-17 stimulation induces NOTCH1 activation in OPCs, contributing to Th17-mediated demyelinating disease. Mechanistically, IL-17R interacts with NOTCH...

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Detalles Bibliográficos
Autores principales: Wang, Chenhui, Zhang, Cun-Jin, Martin, Bradley N., Bulek, Katarzyna, Kang, Zizhen, Zhao, Junjie, Bian, Guanglin, Carman, Julie A., Gao, Ji, Dongre, Ashok, Xue, Haibo, Miller, Stephen D., Qian, Youcun, Hambardzumyan, Dolores, Hamilton, Tom, Ransohoff, Richard M., Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460031/
https://www.ncbi.nlm.nih.gov/pubmed/28561022
http://dx.doi.org/10.1038/ncomms15508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460031/
https://www.ncbi.nlm.nih.gov/pubmed/28561022
http://dx.doi.org/10.1038/ncomms15508

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