Fluorometric evaluation of CYP3A4 expression using improved transgenic HepaRG cells carrying a dual-colour reporter for CYP3A4 and CYP3A7

Primary human hepatocytes are necessary to evaluate cytotoxicity, drug metabolism, and drug–drug interactions for candidate compounds in early-phase drug discovery and development. However, these analyses are often hampered by limited resources and functional or genetic variation among lots. HepaRG...

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Detalles Bibliográficos
Autores principales: Ueyama, Takafumi, Tsuji, Saori, Sugiyama, Takemi, Tada, Masako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460180/
https://www.ncbi.nlm.nih.gov/pubmed/28588200
http://dx.doi.org/10.1038/s41598-017-03146-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460180/
https://www.ncbi.nlm.nih.gov/pubmed/28588200
http://dx.doi.org/10.1038/s41598-017-03146-5

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