Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis

In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro. We optimised a reproducible murine splenocyte MGIA based on in-vitro infection...

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Detalles Bibliográficos
Autores principales: Jensen, Christina, Lindebo Holm, Line, Svensson, Erik, Aagaard, Claus, Ruhwald, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460210/
https://www.ncbi.nlm.nih.gov/pubmed/28588268
http://dx.doi.org/10.1038/s41598-017-02116-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460210/
https://www.ncbi.nlm.nih.gov/pubmed/28588268
http://dx.doi.org/10.1038/s41598-017-02116-1

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