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Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis
In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro. We optimised a reproducible murine splenocyte MGIA based on in-vitro infection...
Autores principales: | Jensen, Christina, Lindebo Holm, Line, Svensson, Erik, Aagaard, Claus, Ruhwald, Morten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460210/ https://www.ncbi.nlm.nih.gov/pubmed/28588268 http://dx.doi.org/10.1038/s41598-017-02116-1 |
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