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Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity

Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistance. Here, we consider not only genetic and epigenetic mechan...

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Detalles Bibliográficos
Autores principales: Wahl, Geoffrey M., Spike, Benjamin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460241/
https://www.ncbi.nlm.nih.gov/pubmed/28649654
http://dx.doi.org/10.1038/s41523-017-0012-z