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Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity
Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistance. Here, we consider not only genetic and epigenetic mechan...
Autores principales: | Wahl, Geoffrey M., Spike, Benjamin T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460241/ https://www.ncbi.nlm.nih.gov/pubmed/28649654 http://dx.doi.org/10.1038/s41523-017-0012-z |
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