Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

Several lines of evidence suggest that components of the tumor microenvironment, specifically basement membrane and extracellular matrix proteins, influence drug sensitivities. We previously reported differential drug sensitivity of tumor cells localized adjacent to laminin-rich extracellular matrix...

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Detalles Bibliográficos
Autores principales: Zoeller, Jason J., Bronson, Roderick T., Selfors, Laura M., Mills, Gordon B., Brugge, Joan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460247/
https://www.ncbi.nlm.nih.gov/pubmed/28649658
http://dx.doi.org/10.1038/s41523-017-0020-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460247/
https://www.ncbi.nlm.nih.gov/pubmed/28649658
http://dx.doi.org/10.1038/s41523-017-0020-z

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