Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes

Myotonic dystrophies (DM1–2) are neuromuscular genetic disorders caused by the pathological expansion of untranslated microsatellites. DM1 and DM2, are caused by expanded CTG repeats in the 3′UTR of the DMPK gene and CCTG repeats in the first intron of the CNBP gene, respectively. Mutant RNAs contai...

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Detalles Bibliográficos
Autores principales: Cerro-Herreros, Estefania, Chakraborty, Mouli, Pérez-Alonso, Manuel, Artero, Rubén, Llamusí, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460254/
https://www.ncbi.nlm.nih.gov/pubmed/28588248
http://dx.doi.org/10.1038/s41598-017-02829-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460254/
https://www.ncbi.nlm.nih.gov/pubmed/28588248
http://dx.doi.org/10.1038/s41598-017-02829-3

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