A semi high-throughput method for screening small bispecific antibodies with high cytotoxicity

Small bispecific antibodies that induce T-cell–mediated cytotoxicity have the potential to damage late-stage tumor masses to a clinically relevant degree, but their cytotoxicity is critically dependent on their structural and functional properties. Here, we constructed an optimized procedure for ide...

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Detalles Bibliográficos
Autores principales: Sugiyama, Aruto, Umetsu, Mitsuo, Nakazawa, Hikaru, Niide, Teppei, Onodera, Tomoko, Hosokawa, Katsuhiro, Hattori, Shuhei, Asano, Ryutaro, Kumagai, Izumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460266/
https://www.ncbi.nlm.nih.gov/pubmed/28588218
http://dx.doi.org/10.1038/s41598-017-03101-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460266/
https://www.ncbi.nlm.nih.gov/pubmed/28588218
http://dx.doi.org/10.1038/s41598-017-03101-4

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