Highly enantioselective metallation–substitution alpha to a chiral nitrile

We report the deprotonation of a chiral nitrile and reaction of the resulting chiral organometallic species with a variety of electrophiles to give highly enantiomerically enriched 2-substituted nitrile products. The nitrile was treated with TMPMgCl and the resulting anion, an asymmetric alpha cyano...

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Detalles Bibliográficos
Autores principales: Sadhukhan, Arghya, Hobbs, Melanie C., Meijer, Anthony J. H. M., Coldham, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460602/
https://www.ncbi.nlm.nih.gov/pubmed/28616143
http://dx.doi.org/10.1039/c6sc03712g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460602/
https://www.ncbi.nlm.nih.gov/pubmed/28616143
http://dx.doi.org/10.1039/c6sc03712g

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