11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity...

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Detalles Bibliográficos
Autores principales: Doig, Craig L., Fletcher, Rachel S., Morgan, Stuart A., McCabe, Emma L., Larner, Dean P., Tomlinson, Jeremy W., Stewart, Paul M., Philp, Andrew, Lavery, Gareth G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460930/
https://www.ncbi.nlm.nih.gov/pubmed/28368470
http://dx.doi.org/10.1210/en.2016-1722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460930/
https://www.ncbi.nlm.nih.gov/pubmed/28368470
http://dx.doi.org/10.1210/en.2016-1722

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