Effects of a Proteasome Inhibitor on Cardiomyocytes in a Pressure-Overload Hypertrophy Rat Model: An Animal Study

BACKGROUND: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of act...

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Detalles Bibliográficos
Autores principales: Kim, In-Sub, Jo, Won-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Thoracic and Cardiovascular Surgery 2017
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460960/
https://www.ncbi.nlm.nih.gov/pubmed/28593149
http://dx.doi.org/10.5090/kjtcs.2017.50.3.144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460960/
https://www.ncbi.nlm.nih.gov/pubmed/28593149
http://dx.doi.org/10.5090/kjtcs.2017.50.3.144

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