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Effects of a Proteasome Inhibitor on Cardiomyocytes in a Pressure-Overload Hypertrophy Rat Model: An Animal Study

BACKGROUND: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of act...

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Detalles Bibliográficos
Autores principales:	Kim, In-Sub, Jo, Won-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society for Thoracic and Cardiovascular Surgery 2017
Materias:	Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460960/ https://www.ncbi.nlm.nih.gov/pubmed/28593149 http://dx.doi.org/10.5090/kjtcs.2017.50.3.144

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