Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasom...

Descripción completa

Detalles Bibliográficos
Autores principales: Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A.B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O’Neill, Luke A., Eltzschig, Holger K., Masters, Seth L., McNamee, Eóin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460990/
https://www.ncbi.nlm.nih.gov/pubmed/28487310
http://dx.doi.org/10.1084/jem.20160462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460990/
https://www.ncbi.nlm.nih.gov/pubmed/28487310
http://dx.doi.org/10.1084/jem.20160462

Ejemplares similares