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Immune checkpoints on innate lymphoid cells

In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phospho...

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Detalles Bibliográficos
Autores principales: Chiossone, Laura, Vivier, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461009/
https://www.ncbi.nlm.nih.gov/pubmed/28515074
http://dx.doi.org/10.1084/jem.20170763
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author Chiossone, Laura
Vivier, Eric
author_facet Chiossone, Laura
Vivier, Eric
author_sort Chiossone, Laura
collection PubMed
description In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti–PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice.
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spelling pubmed-54610092017-12-05 Immune checkpoints on innate lymphoid cells Chiossone, Laura Vivier, Eric J Exp Med News In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti–PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice. The Rockefeller University Press 2017-06-05 /pmc/articles/PMC5461009/ /pubmed/28515074 http://dx.doi.org/10.1084/jem.20170763 Text en © 2017 Chiossone and Vivier http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Chiossone, Laura
Vivier, Eric
Immune checkpoints on innate lymphoid cells
title Immune checkpoints on innate lymphoid cells
title_full Immune checkpoints on innate lymphoid cells
title_fullStr Immune checkpoints on innate lymphoid cells
title_full_unstemmed Immune checkpoints on innate lymphoid cells
title_short Immune checkpoints on innate lymphoid cells
title_sort immune checkpoints on innate lymphoid cells
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461009/
https://www.ncbi.nlm.nih.gov/pubmed/28515074
http://dx.doi.org/10.1084/jem.20170763
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