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Immune checkpoints on innate lymphoid cells
In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phospho...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461009/ https://www.ncbi.nlm.nih.gov/pubmed/28515074 http://dx.doi.org/10.1084/jem.20170763 |
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author | Chiossone, Laura Vivier, Eric |
author_facet | Chiossone, Laura Vivier, Eric |
author_sort | Chiossone, Laura |
collection | PubMed |
description | In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti–PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice. |
format | Online Article Text |
id | pubmed-5461009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54610092017-12-05 Immune checkpoints on innate lymphoid cells Chiossone, Laura Vivier, Eric J Exp Med News In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti–PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice. The Rockefeller University Press 2017-06-05 /pmc/articles/PMC5461009/ /pubmed/28515074 http://dx.doi.org/10.1084/jem.20170763 Text en © 2017 Chiossone and Vivier http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | News Chiossone, Laura Vivier, Eric Immune checkpoints on innate lymphoid cells |
title | Immune checkpoints on innate lymphoid cells |
title_full | Immune checkpoints on innate lymphoid cells |
title_fullStr | Immune checkpoints on innate lymphoid cells |
title_full_unstemmed | Immune checkpoints on innate lymphoid cells |
title_short | Immune checkpoints on innate lymphoid cells |
title_sort | immune checkpoints on innate lymphoid cells |
topic | News |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461009/ https://www.ncbi.nlm.nih.gov/pubmed/28515074 http://dx.doi.org/10.1084/jem.20170763 |
work_keys_str_mv | AT chiossonelaura immunecheckpointsoninnatelymphoidcells AT viviereric immunecheckpointsoninnatelymphoidcells |