Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of...

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Detalles Bibliográficos
Autores principales: Mizutani, Tomohiro, Tsukamoto, Yoshiyuki, Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461034/
https://www.ncbi.nlm.nih.gov/pubmed/28512141
http://dx.doi.org/10.1083/jcb.201704014
Descripción
Sumario:Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

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