Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of...

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Detalles Bibliográficos
Autores principales: Mizutani, Tomohiro, Tsukamoto, Yoshiyuki, Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461034/
https://www.ncbi.nlm.nih.gov/pubmed/28512141
http://dx.doi.org/10.1083/jcb.201704014
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author Mizutani, Tomohiro
Tsukamoto, Yoshiyuki
Clevers, Hans
author_facet Mizutani, Tomohiro
Tsukamoto, Yoshiyuki
Clevers, Hans
author_sort Mizutani, Tomohiro
collection PubMed
description Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.
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spelling pubmed-54610342017-12-05 Oncogene-inducible organoids as a miniature platform to assess cancer characteristics Mizutani, Tomohiro Tsukamoto, Yoshiyuki Clevers, Hans J Cell Biol Commentary Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation. The Rockefeller University Press 2017-06-05 /pmc/articles/PMC5461034/ /pubmed/28512141 http://dx.doi.org/10.1083/jcb.201704014 Text en © 2017 Mizutani et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Mizutani, Tomohiro
Tsukamoto, Yoshiyuki
Clevers, Hans
Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
title Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
title_full Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
title_fullStr Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
title_full_unstemmed Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
title_short Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
title_sort oncogene-inducible organoids as a miniature platform to assess cancer characteristics
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461034/
https://www.ncbi.nlm.nih.gov/pubmed/28512141
http://dx.doi.org/10.1083/jcb.201704014
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AT clevershans oncogeneinducibleorganoidsasaminiatureplatformtoassesscancercharacteristics

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