Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are activated in tumor cells. However, the role of this region in...

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Detalles Bibliográficos
Autores principales: Dave, Kashyap, Sur, Inderpreet, Yan, Jian, Zhang, Jilin, Kaasinen, Eevi, Zhong, Fan, Blaas, Leander, Li, Xiaoze, Kharazi, Shabnam, Gustafsson, Charlotte, De Paepe, Ayla, Månsson, Robert, Taipale, Jussi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461110/
https://www.ncbi.nlm.nih.gov/pubmed/28583252
http://dx.doi.org/10.7554/eLife.23382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461110/
https://www.ncbi.nlm.nih.gov/pubmed/28583252
http://dx.doi.org/10.7554/eLife.23382

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