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Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients

Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically-defined tumor types, coupled wit...

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Detalles Bibliográficos
Autores principales: Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H., Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R., Srinivasan, Preethi, Gao, Jianjiong, Chakravarty, Debyani, Devlin, Sean M., Hellmann, Matthew D., Barron, David A., Schram, Alison M., Hameed, Meera, Dogan, Snjezana, Ross, Dara S., Hechtman, Jaclyn F., DeLair, Deborah F., Yao, JinJuan, Mandelker, Diana L., Cheng, Donavan T., Chandramohan, Raghu, Mohanty, Abhinita S., Ptashkin, Ryan N., Jayakumaran, Gowtham, Prasad, Meera, Syed, Mustafa H., Rema, Anoop Balakrishnan, Liu, Zhen Y., Nafa, Khedoudja, Borsu, Laetitia, Sadowska, Justyna, Casanova, Jacklyn, Bacares, Ruben, Kiecka, Iwona J., Razumova, Anna, Son, Julie B., Stewart, Lisa, Baldi, Tessara, Mullaney, Kerry A., Al-Ahmadie, Hikmat, Vakiani, Efsevia, Abeshouse, Adam A., Penson, Alexander V., Jonsson, Philip, Camacho, Niedzica, Chang, Matthew T., Won, Helen H., Gross, Benjamin E., Kundra, Ritika, Heins, Zachary J., Chen, Hsiao-Wei, Phillips, Sarah, Zhang, Hongxin, Wang, Jiaojiao, Ochoa, Angelica, Wills, Jonathan, Eubank, Michael, Thomas, Stacy B., Gardos, Stuart M., Reales, Dalicia N., Galle, Jesse, Durany, Robert, Cambria, Roy, Abida, Wassim, Cercek, Andrea, Feldman, Darren R., Gounder, Mrinal M., Hakimi, A. Ari, Harding, James J., Iyer, Gopa, Janjigian, Yelena Y., Jordan, Emmet J., Kelly, Ciara M., Lowery, Maeve A., Morris, Luc G.T., Omuro, Antonio M., Raj, Nitya, Razavi, Pedram, Shoushtari, Alexander N., Shukla, Neerav, Soumerai, Tara E., Varghese, Anna M., Yaeger, Rona, Coleman, Jonathan, Bochner, Bernard, Riely, Gregory J., Saltz, Leonard B., Scher, Howard I., Sabbatini, Paul J., Robson, Mark E., Klimstra, David S., Taylor, Barry S., Baselga, Jose, Schultz, Nikolaus, Hyman, David M., Arcila, Maria E., Solit, David B., Ladanyi, Marc, Berger, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461196/
https://www.ncbi.nlm.nih.gov/pubmed/28481359
http://dx.doi.org/10.1038/nm.4333